APJO COVID-19 FAQs

"COVID-19 FAQs" is a one-stop platform that helps you keep abreast of the latest developments in all fronts" said Editors-in-Chief, Dennis Lam & Jost Jonas

1.1b SARS-CoV-2 vs SARS-CoV vs MERS-CoV

References
Lau SKP, Woo PCY, Li KSM, et al. (2005): Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats. Proceedings of the National Academy of Sciences of the United States of America 102: 14040.
Kayali G & Peiris M (2015): A more detailed picture of the epidemiology of Middle East respiratory syndrome coronavirus. The Lancet Infectious Diseases 15: 495-497.
Guan W, Ni Z, Hu Y, et al. (2020): Clinical Characteristics of Coronavirus Disease 2019 in China. New England Journal of Medicine. In press
Zhou P, Yang X-L, Wang X-G, et al. (2020): A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 579: 270-273.

References
Peiris JSM, Guan Y & Yuen KY (2004): Severe acute respiratory syndrome. Nature Medicine 10: S88-S97.
Guan W, Ni Z, Hu Y, et al. (2020): Clinical Characteristics of Coronavirus Disease 2019 in China. New England Journal of Medicine. In press
Weiss SR & Leibowitz JL (2011): Coronavirus Pathogenesis. Advances in Virus Research 81: 85-164.
McBride R, Van Zyl M & Fielding CB (2014): The Coronavirus Nucleocapsid Is a Multifunctional Protein. Viruses 6: 2991-3018.
Fehr AR & Perlman S (2015): Coronaviruses: An Overview of Their Replication and Pathogenesis Coronaviruses: Methods and Protocols. New York, NY.
Matoba Y, Abiko C, Ikeda T, et al. (2015): Detection of the Human Coronavirus 229E, HKU1, NL63, and OC43 between 2010 and 2013 in Yamagata. Japan. Japanese Journal of Infectious Diseases 68: 138-141.
Zhu N, Zhang D, Wang W, et al. (2020): A Novel Coronavirus from Patients with Pneumonia in China, 2019. New England Journal of Medicine 382: 727-733.
Zumla A, Hui DS & Perlman S (2015): Middle East respiratory syndrome. The Lancet 386: 995-1007.

1.2 1918 Spanish Flu historical documentary | Swine Flu Pandemic | Deadly plague of 1918

1.3 Viruses vs. Bacteria | What’s The Difference?

1.4 The Coronavirus Explained & What You Should Do 

1. The coronaviruses

1.1a SARS-CoV-2

q2

Coronaviruses (CoVs) are the largest group of viruses belonging to the Nidovirales order. The name “coronavirus” comes from the Latin “corona”, which means crown, due to its characteristic appearance that resembles a crown or solar corona. CoV can induce respiratory, gastrointestinal and neurological dysfunction in their hosts and predominately respiratory infections in human. 

A total of seven species of coronavirus are found to be pathogenic to humans:

Species (1) HKU1, (2) OC43, (3) NL63 and (4) 229E: Mild upper respiratory tract infections

Species (5) SARS-CoV, (6) MERS-CoV and (7) SARS-2-CoV: Zoonotic and life threatening

1.1b SARS-CoV-2 vs SARS-CoV vs MERS-CoV

References
Lau SKP, Woo PCY, Li KSM, et al. (2005): Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats. Proceedings of the National Academy of Sciences of the United States of America 102: 14040.
Kayali G & Peiris M (2015): A more detailed picture of the epidemiology of Middle East respiratory syndrome coronavirus. The Lancet Infectious Diseases 15: 495-497.
Guan W, Ni Z, Hu Y, et al. (2020): Clinical Characteristics of Coronavirus Disease 2019 in China. New England Journal of Medicine. In press
Zhou P, Yang X-L, Wang X-G, et al. (2020): A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature 579: 270-273.

References
Peiris JSM, Guan Y & Yuen KY (2004): Severe acute respiratory syndrome. Nature Medicine 10: S88-S97.
Guan W, Ni Z, Hu Y, et al. (2020): Clinical Characteristics of Coronavirus Disease 2019 in China. New England Journal of Medicine. In press
Weiss SR & Leibowitz JL (2011): Coronavirus Pathogenesis. Advances in Virus Research 81: 85-164.
McBride R, Van Zyl M & Fielding CB (2014): The Coronavirus Nucleocapsid Is a Multifunctional Protein. Viruses 6: 2991-3018.
Fehr AR & Perlman S (2015): Coronaviruses: An Overview of Their Replication and Pathogenesis Coronaviruses: Methods and Protocols. New York, NY.
Matoba Y, Abiko C, Ikeda T, et al. (2015): Detection of the Human Coronavirus 229E, HKU1, NL63, and OC43 between 2010 and 2013 in Yamagata. Japan. Japanese Journal of Infectious Diseases 68: 138-141.
Zhu N, Zhang D, Wang W, et al. (2020): A Novel Coronavirus from Patients with Pneumonia in China, 2019. New England Journal of Medicine 382: 727-733.
Zumla A, Hui DS & Perlman S (2015): Middle East respiratory syndrome. The Lancet 386: 995-1007.

1.2 1918 Spanish Flu historical documentary | Swine Flu Pandemic | Deadly plague of 1918

1.3 Viruses vs. Bacteria | What’s The Difference?

1.4 The Coronavirus Explained & What You Should Do