11.29 Former FDA chief on Moderna’s early-stage vaccine trial results

21st May 2020 by apjocovid | 0 comments

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Some 60,000 Injected with China’s COVID-19 Vaccines with No Ill Effect – CGTN
– Nearly 60,000 people have been injected with China’s COVID-19 vaccines so far and no one has reported severe adverse reactions, a Chinese official told a press conference on Tuesday. Tian Baoguo, an official from the Ministry of Science and Technology, told reporters that China is leading vaccine development with a total of 13 vaccines in clinical trials.

U.K. Moves Toward Ethically Controversial Coronavirus Vaccine Trial – NPR
– The British government has announced plans for a coronavirus vaccine challenge trial: Volunteers will receive an experimental vaccine and then be deliberately exposed to the coronavirus.

How Dangerous is the Air Around Us? – TODAY
– Scientists are still assessing how dangerous these doses of airborne virus can be – and what we can do to avoid them. Opening a window is one way to keep the air fresh. That’s a bit more complicated in the winter, doesn’t work in all rooms, and certainly doesn’t work on airplanes. The aviation industry says cabin-air is sufficiently filtered and circulated. Some experts say questions remain. But by keeping the air moving with systems like air conditioning, are we decreasing the risk, or merely spreading it?

Top Pandemic Doctor Explains Hong Kong’s Low Covid-19 Fatality Rate – Bloomberg
– Hong Kong’s top pandemic doctor sees a way out of intensive care for thousands of Covid-19 patients: keeping them from entering in the first place. After sobering experiences 17 years ago with the outbreak of SARS, Yuen Kwok-Yung is advocating early, aggressive hospitalization and treatment to minimize ravaging disease and death. Hong Kong’s 2% Covid-19 fatality rate as of Friday, well below the global average, lends weight to the approach.

A Global View of the Worsening Coronavirus Crisis – PBS NewsHour
– Across the globe, new cases of the coronavirus have climbed to an all-time high of more than 330,000 per day. Continental Europe is facing unprecedented spread, but conditions are worsening in the United Kingdom and in parts of Latin America, as well. Nick Schifrin and special correspondents Lucy Hough, Malcolm Brabant and Mary Triny Mena have a worldwide look at the worsening pandemic.

European Countries Rush to Slow Spread of COVID – DW News
– Countries across Europe are imposing tighter restrictions in the hope of slowing the spread of the coronavirus – as cases continue to rise. France has recorded a new high of 32 thousand cases in a single day. Authorities have brought in a curfew in major cities requiring all public spaces to be shut by 9pm. But not everyone has welcomed the new rules.

Europe’s Tough Restrictions ‘Absolutely Necessary – BBC
– WHO has warned that tough restrictions are “absolutely necessary” to save lives. Millions in Europe have been told they must live under strict new measures as governments battle a second wave.

WHO Study Raises Doubts Over Donald Trump’s Favoured Covid-19 Treatments – SCMP
– Study concludes that four treatments had little to no effect on hospitalised patients, but scientists say drugs may still help in early stage of illness. One of the treatments, remdesivir, was given to the US president after he tested positive for coronavirus earlier this month.

US Study Reveals Risks of Virus Transmission in Playing Wind Instruments – SCMP
– Study conducted by the University of Minnesota and published in the Journal of Aerosol Science says findings could provide ‘valuable insights’. The playing of trumpet, oboe and bass trombone is considered a ‘high-risk’ activity, while most other wind instruments pose ‘intermediate’ risk.

Direct Detection of SARS-CoV-2 Using CRISPR-Cas13a and a Mobile Phone – MedrXiv
– The study combined crRNAs targeting SARS-CoV-2 RNA to improve sensitivity and specificity, and we directly quantified viral load using enzyme kinetics. Combined with mobile phone-based quantification, this assay can provide rapid, low-cost, point-of-care screening to aid in the control of SARS-CoV-2.

Macron Announces Curfew for Paris and Eight Other French Cities – CGTN
– French President Emmanuel Macron on Wednesday announced a night-time curfew in Paris and eight other cities to control the spread of the coronavirus in the country.

Trump’s Son Barron Had Coronavirus, says First Lady – BBC
– US President Donald Trump’s 14-year-old son Barron contracted coronavirus but has since tested negative, First Lady Melania Trump revealed. Mrs Trump said her “fear came true” when Barron tested positive for Covid-19. But, she said, “luckily he is a strong teenager and exhibited no symptoms”.

Covid Reinfection: Man Gets Covid Twice And Second Hit ‘More Severe’ – BBC
– A man in the United States has caught Covid twice, with the second infection becoming far more dangerous than the first, doctors report. The 25-year-old needed hospital treatment after his lungs could not get enough oxygen into his body.

Coronavirus Reinfections Are Real but Very, Very Rare – New York Times
– A case in Nevada has spurred new concerns that people who have recovered from the infection may still be vulnerable. That’s unlikely, experts say.

The Race for a Super-Antibody Against the Coronavirus
– New York Times
– A network of scientists is chasing the pandemic’s holy grail: an antibody that protects against not just the virus, but also related pathogens that may threaten humans.

Hong Kong Researchers Find Common Ulcer Drug Could Be Effective in Halting Coronavirus Replication in Patients – SCMP
– Researchers say the drug could be as effective as the new Covid-19 drug remdesivir, which is currently in short supply amid the pandemic. The medication, which contains the metal bismuth, works by interrupting the process by which the virus replicates inside cells.

Covid Virus ‘Survives for 28 days’ in Lab Conditions – BBC
– The virus responsible for Covid-19 can remain infectious on surfaces such as banknotes, phone screens and stainless steel for 28 days, researchers say.

Johnson & Johnson Pauses Covid-19 Vaccine Trials Due to Sick Subject – Wall Street Journal
– Johnson & Johnson said it has paused further dosing in all clinical trials of its experimental Covid-19 vaccine because a study volunteer had an unexplained illness. The pause announced Monday affects all trials of J&J’s vaccine, including a large Phase 3 trial that began in September and aimed to enroll as many as 60,000 people in the U.S. and several other countries.

Inhaled Vaccines Under Development in Hong Kong Aim to Fight Coronavirus at Its Point of Attack – SCMP
– Researchers are looking at whether they can get better protection from inoculations that fight the virus at its point of attack – the nose and mouth. Sprayed and inhaled immunisations under development in Hong Kong, the US and UK could play an important role in helping society escape restrictions.

Would Herd Immunity Stop the Spread of Coronavirus? – The Guardian
– Like the Covid-19 virus itself, the idea of herd immunity has surged back into public life having been suppressed for months. It was initially touted as a way to hold back the pandemic – by allowing sufficient numbers of infections to occur and so reduce numbers of non-immune potential hosts for the virus. The disease would then stop spreading, it was argued.

Three Ways Hong Kong Airport Coronavirus Screening Could Be Made Faster and Safer
– SCMP
– All the check points at the airport are well organised and staff deserve praise for their diligent work. However, fewer check points would help prevent passengers from different flights mingling and reduce the need for contact tracing.

Dr. Scott Gottlieb: Antibody Drugs May Be Helpful Virus Treatments, But Won’t End U.S. Epidemic – CNBC
– “I think these drugs will make a meaningful difference for people who are the highest risk of having a bad outcome,” Dr. Scott Gottlieb said of coronavirus antibody treatments. “But this is not going to end the epidemic. This is not going to be wildly available to everyone,” he told CNBC. Gottlieb said the U.S. should try to develop a national strategy to expand manufacturing capacity.

Covid Cases Increase Rapidly As Next Steps Planned – BBC
– Coronavirus cases in England have “increased rapidly”, data shows, as ministers grapple with what to do next. Estimates suggest between one-in-170 and one-in-240 people you meet in the street has the virus. Both current cases, and the speed at which they are increasing, are much higher in the north of England than the national average.

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在現時缺乏安全有效的疫苗和藥物的情況下，強制全民口罩也許是預防和消除COVID-19的最大希望。想知道更多詳情，請瀏覽：

11.29 Former FDA chief on Moderna’s early-stage vaccine trial results

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